有机磷试剂在不对称反应中的应用

Studies on the application of organophosphorus reagents in asymmetric reactions

由于其结构多样性,有机磷化合物作为配体、催化剂、辅助剂、添加剂、底物以及试剂等在不对称反应中均获得了成功的应用,从而使有机磷试剂在不对称反应研究领域占有举足轻重的地位.本文全面介绍了本课题组近几年来围绕有机磷试剂在不对称反应中的应用,在醛的不对称硅氰化反应、内消旋环氧烷不对称开环反应、潜手性酮的不对称硼烷还原、不对称Friedel-Crafts烷基化、对映选择Mitsunobu、不对称aza-Morita-Baylis-Hillman、不对称aza-Henry以及硝基烯的不对称Michael加成反应等方面所取得的一些研究结果.

Owning to their structure diversity,organophosphorus compounds play an outstanding role in the asymmetric tranformations.They have been successfully employed as chiral ligand,chiral catalyst,chiral auxiliary,additive,substrate as well as chiral reagent in different type of asymmetric reactions.This account outlines our efforts on the application of organophosphorus compounds in some asymmetric reactions during the past seveval years,such as silylcyanation of aldehydes,desymmetrization of meso epoxide,Friedel-Crafts alkylation of indole,Michael addition to nitroolefins,aza-Henry reaction,aza-Morita-Baylis-Hillman reaction,borane reduction of prochiral ketones.