血清抵抗素水平与高血压的相关性

Relationship between serum resistin concentration and hypertension

目的:研究血清抵抗素水平与高血压的相关性。方法:选择50例无糖尿病病史的高血压患者(高血压组)和40例体检正常者(对照组),收集一般临床资料,测量血压、腰围、臀围,测定空腹血糖、空腹胰岛素、高敏C反应蛋白(hsCRP)等生化指标,采用ELISA法测定2组血清抵抗素水平,并用胰岛素抵抗指数(IRI)作为胰岛素敏感性评价指标。结果:高血压组患者其腰围,BMI,血压,IRI,hsCRP和抵抗素水平较正常对照组高(均P<0.05),高血压组患者血清抵抗素与腰围、收缩压、IRI及hsCRP呈正相关(r值分别为0.391,0.425,0.608,0.447,均P<0.05),对照组血清抵抗素与IRI及hsCRP呈正相关(r值分别为0.406,0.452,均P<0.05)。经Logistic多因素回归分析发现腰围、IRI、hsCRP及抵抗素与高血压相关(OR值分别是1.042、1.368、1.129、1.082,均P<0.05)。结论:血清抵抗素水平与高血压炎症和胰岛素抵抗密切相关,提示抵抗素可能通过炎症,胰岛素抵抗在高血压发病过程中起重要作用。

Objective：To study the relationship between serum resistin concentration and hypertension.Method：The basic information was collected in fifty hypertensive patients without diabetic history and in forty normal people as control.Blood pressure,waist circumference and hip circumference were measured.Then blood samples were taken from them for measurement of biochemical indicators such as fasting plasma glucose,fasting insulincand hs-ERP.Fasting serum resistin was tested by enzyme linked immunosorbent assay （ELISA）.Insulin resistance index （IRI） was applied to estimate insulin scnsitivity.Result：The levels of waist circumference,BMI,blood pressure,IRI,hsCRP and serum resistin were significantly higher in the hypertensive patients than those in normal control group （P0.05）.Pearson relation analysis showed that the resistin level of the hypertensive patients was positively correlated with waist circumference （r=0.391,P0.05）,systolic blood pressure （r=0.425,P0.05）,IRI （r=0.608,P0.05） and hsCRP （r=0.447,P0.05）.In normal control group,the resistin level was positively correlated with IRI （r=0.406,P0.05） and hsCRP （r=0.452,P0.05）.Multiple factor Logistic regression analysis showed that waist circumference （OR=1.042,P0.05）,IRI （OR=1.368,P0.05）,hsCRP （OR=1.129,P0.05） and resistin （OR=1.082,P0.05） were associated with hypertension.Conclusion：The results suggest that the and of resistin is associated with systemic inflammation and insulin resistance in hypertensive patients.The resistin may play pivotal roles in the pathogenesis and development of hypertension through systemic inflammation and insulin resistance.