无环鸟苷与聚肌胞联合治疗口腔单纯疱疹的疗效

The efficacy of acyclovir combined with poly I∶C in the treatment of oral herpes simplex

目的：了解无环鸟苷与聚肌胞联合治疗口腔单纯疱疹感染的效果。方法：以无环鸟苷为抗病毒局部涂擦药物，配以肌注聚肌胞免疫增强剂为全身用药，并以素高捷疗口腔膏与肌注ＶｉｔＢ１２为对照组。结果：实验组与对照组相比，有显著性差异，（χ２＝１０．７１，Ｐ＜０．０１），治愈天数缩短（Ｐ＜０．０１），全身症状轻于对照组，复发时间也相应延长。

Objective: To observe the efficacy of acyclovir (AVC) combined with Poly I∶C (PIC) in the treatment of oral herpes simplex (OHS). Method:56 cases of OHS were treated by local smearing of AVC paste and intramuscular injection of PIC; 46 cases of OHS were treated by local smearing of Solcoseryl dental adhesive paste and intramuscular injection of Vit B 12 as the control. The effects were observed clinicaly.Result:The ratios of effectiveness in the tested and contral groups were 100% and 88.2% respectively( P <0.01); the times for the disapearance of the symptoms in the two groups were 5.4 and 6.45 days respectively( P <0.01).Conclusion:The combination of AVC with PIC is effective in the treatment of OHS.