Drug dependence and abuse potential of tramadol

Drug dependence and abuse potential of tramadol 1

目的：在２１９例有曲马朵滥用史的阿片成瘾者中评价曲马朵的药物依赖性和滥用潜力．方法：采用阿片戒断症状量表（ＯＷＳ）评价曲马朵身体依赖性；采用中文成瘾研究中心问卷（ＡＲＣＩＣＶ）评价曲马朵精神依赖性；采用视觉类比量表（ＶＡＳ）评价曲马朵的渴求程度．结果：曲马朵ＯＷＳ各项戒断症状分值为００５－１０７；ＡＲＣＩ测量药物欣快效应的ＭＢＧ分量表，测量镇静效应的ＰＣＡＧ分量表和测量拟精神病效应的ＬＳＤ分量表的平均值分别是７３，６１和３４（Ｆ＝３８１２，Ｐ＜００１）；５７１％的曲马朵滥用者对曲马朵有不同程度的渴求（χ２＝７５８６，Ｐ＜００１）．结论：曲马朵在阿片成瘾者中具有较高滥用潜力．

AIM: To assess the drug dependence and abuse liability of tramadol. METHODS: Subjects of opiate addicts with history of tramadol abuse were 219. Physical dependence of tra￣madol was assessed using opiate withdrawal scale (OWS), psychic dependence was assessed by association test of Addiction Research Center Inventory Chinese Version (ARCI CV); the degrees of craving experienced for tramadol was self reported on visual analogue scale (VAS). RESULTS: The scores of OWS of tramadol were 0 05-1 07; 3 scores on scales in particular being used the identify euphoric effects — MBG, sedative effects — PCAG, and psychotomimetic effects — LSD of ARCI were 7 3, 6 1, and 3 4, respectively ( F =38 1, P <0 01); 57 1 % of tramadol abuse subjects had craving for tramadol (χ 2=75 86, P <0 01). CON￣CLU￣SION: Tramadol pro￣duced high abuse potential among opiate addicts.