卡孕栓预防阴道分娩子宫收缩乏力性产后出血的疗效观察

Clinical Efficacy of Gemeprost for Postpartum Hemorrhage Caused by Utrine Atony after Vaginal Delivery

目的:观察卡孕栓预防阴道分娩子宫收缩乏力性产后出血的疗效。方法:选择我院2008年10月～12月分娩的产妇共240例,随机分为卡孕栓组120例,于产后给予卡孕栓1粒舌下含服;缩宫素组120例,于产后给予10U缩宫素静脉推注。比较2组术后出血情况和副作用。结果:卡孕栓组发生产后出血3例(2.5%),缩宫素组发生产后出血8例(6.7%),2组比较有显著性差异(P<0.05)。卡孕栓组产后2h出血量为(260.2±52.6)mL,缩宫素组为(356.4±56.8)mL,2组比较有显著性差异(P<0.01)。2组均未见严重副作用。结论:卡孕栓预防阴道分娩子宫收缩乏力性出血较缩宫素安全、快速、有效。

OBJECTIVE：To investigate the clinical efficacy of gemeprost for the prevention of postpartum hemorrhage caused by utrine atony after vaginal delivery.METHODS：240 delivery women in our hospital from Oct.to Dec.2008 were divided into gemeprost group and oxytocin group.Gemeprost group were given sublingual administration of gemeprost （1 pellet） and oxytocin group were given intravenous injection of 10 U oxytocin after delivery.Postpartum hemorrhage and adverse reaction of 2 groups were compared.RESULTS：3 cases of postpartum hemorrhage （2.5%） were found in gemeprost group,while 8 cases （6.7%） were found in oxytocin group （P0.05）.The volumes of postpartum hemorrhage within two hours were （260.2±52.6） mL in gemeprost group and （356.4±56.8） mL in oxytocin group,there was significant difference between 2 groups （P0.01）.Serious adverse reaction wasn＇t found in 2 groups.CONCLUSION：Gemeprost is more rapid,safe and effective than oxytocin in the prevention of postpartum hemorrhage caused by utrine atony after vaginal delivery.