国产奥曲肽治疗肝硬化食管胃底静脉曲张破裂出血的疗效观察

Efficacy Observation of Domestic Octreotide Acetate in the Treatment of Esophageal and Gastric Varices Bleeding

目的:观察国产奥曲肽治疗肝硬化食管胃底静脉曲张破裂出血的临床疗效。方法:218例患者随机分为治疗组(110例)和对照组(108例),分别给予国产奥曲肽和进口醋酸奥曲肽100μg缓慢静脉推注后以25μg·h-1的速度静脉微量泵持续泵入。结果:治疗组显效率为50.90%,有效率为32.72%,总有效率为83.62%;对照组显效率为50.00%,有效率为34.26%,总有效率为84.26%。2组有效率比较无显著性差异(P>0.05)。结论:国产奥曲肽在治疗肝硬化食管胃底静脉曲张破裂出血方面可达到进口奥曲肽水平。

OBJECTIVE：To observe clinical efficacy of domestic octreotide acetate in treatment of Esophageal and gastric Varices Bleeding.METHODS：218 patients were randomized into treatment group （n=110） and control group （n=108）.Both groups were given domestic octreotide acetate 100 μg and imported octreotide acetate 100 μg respectively with continuous pump infusion rate of 25 μg·h-1 intravenously.RESULTS：In treatment group excellence rate was 50.09%,effective rate 32.72% and total response rate 83.62%;in control group excellence rate was 50.00%,effective rate 34.26% and total response rate 84.26%.There was no significant difference in effective rate between 2 groups （P0.05）.CONCLUSION：Domestic octreotide acetate have same effect to imported octreotide acetate in the treatment of Esophageal and gastric Varices Bleeding which is caused by portal hypertension in patients with decompensated liver cirrhosis.Stopping bleeding rate of the achieved the similar level with.