新癀片联合阿奇霉素与0.1%阿达帕林凝胶治疗寻常型痤疮的疗效观察

Clinical Efficacy of Xinhuang Tablets Combined with Azithromycin Granules and Adapalene Gel in the Treatment of Acne Vulgaris

目的:观察新癀片联合阿奇霉素、0.1%阿达帕林凝胶治疗寻常型痤疮的疗效。方法:将216例Ⅰ、Ⅱ度寻常型痤疮患者根据就诊顺序随机分为治疗组和对照组各108例。治疗组应用新癀片、阿奇霉素口服加外用0.1%阿达帕林凝胶进行治疗;对照组应用红霉素肠溶片口服加外用复方硫磺洗剂。疗程满6周后观察2组疗效。结果:治疗组总有效率为97.2%,对照组总有效率为41.6%,2组比较有显著性差异(P<0.01)。在6周的临床试验中,治疗组的不良反应发生率明显低于对照组(P<0.05)。结论:新癀片联合阿奇霉素、0.1%阿达帕林凝胶治疗Ⅰ、Ⅱ度寻常型痤疮可明显缓解病情、缩短病程,且不良反应轻微。

OBJECTIVE：To observe the clinical efficacy of Xinhuang tablets combined with Azithromycin granules and 0.1% Adapalene gel in the treatment of acne vulgaris.METHODS：216 patients with acne vulgaris were randomly divided into experimental group and control group according to visiting order （n=108）.Experimental group were treated with oral administration of Xinhuang tablets and Azithromycin granules and 0.1% Adapalene gel for external use.Control group were treated with Erythromycin enteric-coated tablets and Compound sulfur lotion.Clinical efficacies of 2 groups were observed after 6 weeks.RESULTS：Total effective rate was 97.2% for experimental group and 41.6% for control group.There was significant difference between 2 groups （P0.01）.The incidence of adverse drug reactions （ADR） in experimental group were significantly different from control group （P0.05）.CONCLUSION：Xinhuang tablets combined with Azithromycin granules and 0.1% Adapalene gel have sound effect on acne vulgaris,but has little side-effects.