缺血性脑血管病颈动脉斑块危险因素探讨

Risk Factors of Carotid Artery Plaque in Ischemic Cerebrovascular Disease

目的探讨缺血性脑血管病患者颈动脉粥样硬化斑块与其他危险因素的关系。方法对240例缺血性脑血管病患者及142例健康体检者进行彩色多普勒超声检测颈动脉内-中膜厚度(IMT)、斑块数和性状及血生化检查,包括总胆固醇(CH)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、血浆肌酐、纤维蛋白原(FIB)、血小板聚集度(PAG)。结果缺血性脑血管病组颈内动脉粥样斑块77.5%与对照组21.13%比较差异有统计学意义(P<0.01)。有高血压、糖尿病更易引起颈动脉粥样硬化(P<0.01)。结论颈动脉粥样硬化与缺血性脑血管病关系密切,高血压、糖尿病在斑块形成中起重要作用。而甘油三酯、总胆固醇、低密度脂蛋白胆固醇也影响动脉斑块的形成。

Objective To investigate atherosclerotic plaques in patients with ischemic cerebrovascular disease and the risk factors.Methods In 240 patients with ischemic cerebrovascular disease and 142 healthy control,color Doppler ultrasonography was used to check its carotid intima-media thickness（IMT）,plaques and traits;total cholesterol（CH）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL）,low-density lipoprotein cholesterol（LDL）,plasma creatinine,fibrinogen（FIB）,platelet aggregation degree（PAG）were examined.Results In the schemic cerebrovascular disease group,77.5% of them had internal carotid artery plaque,and in healthy control,the rate was 21.13%,the difference was significant（P0.01）.Hypertension and diabetes were more likely to lead to atherosclerosis（P0.01）.Conclusion Carotid atherosclerosis and ischemic cerebrovascular disease was closely correlated.Hypertension and diabetes mellitus played an important role in plaque formation.Triglyceride,total cholesterol and low-density lipoprotein cholesterol also influenced the formation of arterial plaque.