摘要
恶性胶质瘤(MG)是颅内常见的原发性肿瘤。其中,多形胶质母细胞瘤(GBM)是恶性程度最高的肿瘤,GBM呈浸润性生长,单纯手术往往难以彻底根除,术后复发率很高,中位生存期(MST)多为9—15个月。近年来GBM的临床治疗取得了一些进展,许多学者越来越重视手术后的其他治疗方法,包括放疗、化疗、分子靶向治疗等。
出处
《癌症进展》
2010年第4期384-388,共5页
Oncology Progress
参考文献30
-
1Reardon DA,Rich JN,Friedman HS,et al.Recent advances in the treatment of malignant astrocytoma[J].J Clin Oncol,2006,24(8):1253.
-
2Sathornsumetee S,Rich JN,Reardon DA.et al.Diagnosis and treatment of high-grade astrocytoma[J].Neurol Clin,2007,25(4):1111.
-
3Kanu OO,Mehta A,Di C,et al.Glioblastoma multiforme:A review of therapeutic targets[J].Expert Opin Ther Targets,2009,13(6):701.
-
4Stupp R,Roila F.Malignant glioma:ESMO clinical recommendations for diagnosis,treatment and follow-up[J].Ann Oncol,2009,Suppl 4:126.
-
5Olson JJ,Fadul CE,Brat DJ,et al.Management of newly diagnosed glioblastoma:Guidelines development,value and application[J].J Neurooncol,2009,93(1):1.
-
6Boa W.Abbreviated course of radiation therapy in older patients with glioblastoma multiforme:A prospective randomized clinical trial[J].J Clin Oncol,2004,22:1583.
-
7Darakchiev BJ,Albright RE,Breneman JC,et al.Safety and efficacy of permanent iodine-125 seed implants and carmustine wafers in patients with recurrent glioblastoma multiforme[J].J Neurosurg,2008,108(2):236.
-
8Villavicencio AT,Burneikiene S,Romanelli P,et al.Survival following stereotactic radiosurgery for newly diagnosedand recurrent glioblastoma multiforme:A multicenter experience[J].Neurosurg Rev,2009,32(4):417.
-
9Brandes AA,Tosoni A,Franceschi E.Adjuvant therapy in glioblastomas:False steps and real advances[J].Expert Rev Anticancer Ther,2007,7(5):607.
-
10WestphalM,Hilt DC,Bortey E,et al.A phase 3 trial of local chemotherapy with biodegradable carmistine(BCNU)wafers in patients with primary malignant gliomas[J].Neuro-Oncol,2003,5:79.
同被引文献22
-
1易海波,石松生,杨卫忠,陈春美.Notch-1基因在人脑胶质瘤中的表达及其意义[J].肿瘤防治研究,2006,33(10):701-703. 被引量:13
-
2贾延劼,孙吉平,朱晓峰,连亚军,王海珍,张璐,张博爱.Notch-1在骨髓间质干细胞分化为神经细胞中的作用[J].中华医学杂志,2006,86(41):2916-2921. 被引量:10
-
3Purow BW,Haque RM,Noel MW,et al.Expression of Notch1 and it s ligands,Delta-like-1 and Jagged-1,is critical for glioma cell survival and proliferation.Cancer Res,2005,65:2353-2363.
-
4罗世琪.胶质母细胞瘤.见:王忠诚主编.王忠诚神经外科学.武汉:湖北科学技术出版社,2005:546-548.
-
5Nakada M,Nakada S,Demuth T,et al.Molecular targets of glioma invasion.Cell Mol Life Sci,2007,64:458-478.
-
6Morrison SJ,Perez SE,Qiao Z,et al.Transient Notch activation initiates anirreversible switchfromneurogenesis to gliogenesis by neural crest stem cells.Cell,2000,101:499-510.
-
7Grandbarbe L,Bouissac J,Rand M,et al.Delta-Notch signalling controls the generation of neurons/glia from neural stem cells in a stepwise process.Development,2003,130:1391-1402.
-
8Weijzen S,Zlobin A,Braid M,et al.HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation.J Cell Physiol,2003,194:356-362.
-
9Yasutomo K,Doyle C,Miele L,et al.The duration of antigen receptor signalling determines CD4 + versus CD8 + T-cell lineage fate.Nature,2000,404:506-510.
-
10Nickoloff BJ,Qin JZ,Chaturvedi V,et al.Jagged-1 mediated activation of notch signaling inluces complete maturation of human keratinocytes through NF-kappaB and PPAR gamma.Cell Death Differ,2002,9:842-855.
引证文献2
-
1王建鹏,姚维成,栗世方,孙晓朋.下调Notch-1基因表达抑制胶质母细胞瘤的增殖活性研究[J].中华神经外科杂志,2011,27(2):140-143. 被引量:1
-
2周绍兵,刘阳晨,尹小祥,高飞,郭信伟,丁文秀.三维适形放疗联合三苯氧胺治疗恶性脑胶质瘤术后患者的疗效观察[J].中国肿瘤临床与康复,2014,21(10):1232-1234. 被引量:2
二级引证文献3
-
1刘永敏,段萍,黄春田,李博,韩雪飞,许燕,鄢文海,邢莹.慢病毒Tet-On系统调控Notch1-EGFP融合蛋白在PC12细胞中表达的研究[J].中国应用生理学杂志,2013,29(3):232-237. 被引量:5
-
2周绍兵,刘阳晨,尹小祥,郭信伟,古亮,丁文秀.恶性脑胶质瘤术后三维适形放疗联合三苯氧胺治疗的临床观察[J].现代肿瘤医学,2015,23(24):3582-3585. 被引量:4
-
3陈岚,陈巍,李硕果.贞芪扶正胶囊联合他莫昔芬治疗雌激素受体阳性乳腺癌的临床研究[J].现代药物与临床,2018,33(5):1172-1175. 被引量:6
-
1刁新峰,李新茂,张婷,郑新成,张方成,魏志玄.幕上多形胶质母细胞瘤56例临床分析[J].广东医学,2015,36(8):1197-1200. 被引量:3
-
2毕利萍,徐国镇.多形胶质母细胞瘤的综合治疗进展[J].医学综述,2014,20(4):649-652. 被引量:4
-
3尹昱,闫桂芳,贾子善,赵振彪,康宇华.多形性胶质母细胞瘤颅外转移1例[J].临床荟萃,2011,26(13):1177-1178. 被引量:1
-
4张照立,程永立.脑胶质瘤的综合治疗[J].中国社区医师(医学专业),2004,6(10):2-3.
-
5林立,王学忠,王利锋,张蕴增,刘续磊,李瑞峰.脑胶质母细胞瘤手术综合治疗及疗效预后分析[J].职业与健康,2010,26(24):3051-3052.
-
6展如才,王成伟.诱导分化治疗脑胶质瘤的研究进展[J].中国临床神经外科杂志,2008,13(7):442-445. 被引量:1
-
7李俊杰,王博,毕智勇,邸飞.高级别脑胶质瘤术后三维适形放疗联合替莫唑胺化疗的疗效分析[J].湖南中医药大学学报,2013,33(10):11-11. 被引量:9
-
8张庆军,肖全平,鲍伟宇,杨冠武,张森.CT扫描在星形细胞瘤诊断和分级中的价值[J].中国实用神经疾病杂志,2007,10(7):114-114.
-
9徐庚,丁育基.功能区皮层下多形胶质母细胞瘤手术方法的探讨[J].中华外科杂志,1998,36(12):753-755. 被引量:3
-
10李凤琪,章步文,黄小燕.MR-ADC值对脑脓肿和多形胶质母细胞瘤鉴别诊断的价值[J].中华肿瘤防治杂志,2011,18(4):284-287. 被引量:6