摘要
目的:探讨血脂康胶囊对动脉粥样硬化大鼠血脂及血清C反应蛋白的影响。方法:健康成年大鼠24只,随机分成假手术组(Sham组,n=8),动脉粥样梗化模型组(AS组,n=8),血脂康治疗组(XZK组,n=8)。4w后,测定血液流变学参数,用自动生化分析仪测定总胆固醇(TC)、三酰甘油(TG)、血清低密度脂蛋白胆固醇(LDL-C),酶联免疫吸附法(ELISA)检测血清CRP水平。结果:与Sham组相比,AS组和XZK治疗组大鼠全血的切粘度、血清的TC、TG、LDL-C、CRP水平升高(均P<0.05);与AS组比较,XZK治疗组大鼠全血的切粘度、血清的TC、TG、LDL-C、CRP水平降低(均P<0.05)。结论:血脂康胶囊能降低动脉粥样硬化大鼠血清TC、TG、LDL-C,可能机制之一是通过降低血清C反应蛋白的水平。
Objective：To investigate effects of Xuezhikang capsule on the content of blood fat and C-reactive protein of rats with atherosclerosis.Methods：A total of healthy twenty-four Wistar rats were randomly divided into Sham（n=8） group and Atherosclerosis（AS,n=8） group and Xuezhikang treated group（XZK group,n=8）.After 4 weeks,we measured hemorheological parameters,the level of serum TC,TG,LDL-C,CRP.Results：The value of whole blood shear viscosity and the level of serum TC,TG,LDL-C,CRP in AS and XZK group were significantly highter than those in Sham groups（P0.05）.Compared with rats in AS group,the value of whole blood shear viscosity,the content of serum TC,TG,LDL-C,CRP were significantly lower in XZK treated group（P0.05）.Conclusion：Xuezhikang capsule can downregulate the level of serum TC,TG,LDL-C,CRP,Downregulating the level of CRP is one of these mechanisms.
出处
《现代生物医学进展》
CAS
2010年第12期2263-2265,共3页
Progress in Modern Biomedicine
