血必净注射液对AOPP患者血清TNF-a、IL-10的干预研究

Intervention of Xuebijing Injection in Serum TNF-a and IL-10 of Patients with Acute Organophosphorus Pesticide Poisoning

目的:探讨血必净注射液对AOPP患者血清TNF-a、IL-10的干预作用。方法:将40例AOPP患者随机分为两组:常规治疗组(20例)给于洗胃、胆碱酯酶复能剂、阿托品、长托宁及对症支持治疗,血必净治疗组(20例)在常规治疗的基础上加用血必净注射液,空白对照组为医院健康体检者(20例)。观察AOPP两组1、3、5、7天血清TNF-a、IL-10的变化水平。结果:两组患者在入院第一天治疗前机体炎性因子TNF-a、IL-10较空白对照组明显升高,但两组差异无统计学意义(P>0.05),两组与空白对照组比较差异均有统计学意义(P<0.01),治疗3天后血必净治疗组机体炎性因子TNF-a、IL-10较常规治疗组明显降低,两组之间差异有统计学意义(P<0.05)。结论:血必净注射液可以明显减低AOPP患者血清炎性因子的水平,改善其预后,降低死亡率。

Objective：To explore the intervention effect of Xuebijing injection in serum TNF-a and IL-10 of patients with acute organophosphorus pesticide poisoning Methods：40 patients with severe AOPP were randomly divided into 2 groups：routine treatment group（20 example）：to provide Gastric Lavage,cholinesterase reinvocation agent,atropine,Penehyclidine Hydrochloride Injection and Supporting Therapy.Xue Bi Jing treatment group（20 example）：in background of routine treatment adding Xue Bi Jing,health examination persons were blank control group（（20 example）.to observation variation level of TNF-a,IL-10 in blood serum in patients with AOPP.Results：2 treatment groups were no significantly difference（P0.05）,more significantly than blank control group（P0.01）.After 3 days of treatment,TNF-a,IL-10 in Xue Bi Jing treatment group were decreased more significantly than those of routine treatment group.Conclusion：Xue Bi Jing can apparently reduce level of TNF-a,IL-10 in blood serum in patients with AOPP,and then improve Prognosis,reduce mortality.