VEGF、MMP-2与MMP-9在卵巢癌组织中的表达及其临床意义

Expression and clinical significance of VEGF,MMP-2 and MMP-9 in ovarian carcinoma

目的:探讨VEGF、MMP-2和MMP-9在卵巢癌组织中的表达及其与卵巢癌发生发展的关系。方法:采用免疫组织化学法检测VEGF、MMP-2和MMP-9在正常卵巢组织、卵巢癌组织中的表达,并对三者的相关性进行分析。结果:卵巢癌组织中VEGF、MMP-2和MMP-9蛋白的表达阳性率显著高于正常卵巢组织(P<0.05),且在卵巢癌III～IV期患者标本中阳性率高于I～II期(P<0.05);VEGF、MMP-2和MMP-9蛋白阳性表达率与卵巢癌临床分期和淋巴结转移有关(P<0.05)。结论:正常卵巢组织和卵巢癌组织中VEGF、MMP-2和MMP-9蛋白含量的变化一致;VEGF、MMP-2和MMP-9均参与了卵巢癌的发生发展过程,三者间可能有协同作用。

Objective：To investigate the expression of VEGF,MMP-2 and MMP-9 in ovarian carcinomas and their correlations to oncogenesis and progression of ovarian cancer Methods：The levels of VEGF,MMP-2 and MMP-9 were tested by immunohistochemical technology.And the relationship among the expressions of three genes as well as the relationship between them was analyzed.Results：The positive rates of VEGF,MMP-2 and MMP-9 were significantly higher in patients with ovarian carcinoma than those in normal controls（P0.05）,and their positive rate in those of clinical stage Ⅲ~Ⅳwas higher than stageⅠ~Ⅱ（P0.05）.The positive rate of VEGF,MMP-2 and MMP-9 were correlated with clinical stage and lymph node metastasis（P0.05）.Conclusion：The changes in positive rates of VEGF,MMP-2 and MMP-9 proteins in ovarian cancer are accordant to the changes in normal ovarian tissue.VEGF,MMP-2 and MMP-9 may cooperate with each other in tumor invasion and metastasis.