摘要
黑色素瘤特异性抗原（preferentially expressed antigen of melanoma,PRAME）基因作为泛白血病标志可用于微小残留白血病检测,并对疗效、预后、危险度分级及复发预测具有一定意义.此外,PRAME作为肿瘤相关抗原,可被细胞毒性T细胞识别,是白血病免疫治疗的理想靶点,对PRAME基因启动子区CpG岛甲基化的深入研究有助于理解PRAME基因在白血病中的表达机制及与白血病发生之间的关系.
The gene of preferentially expressed antigen of melanoma（PRAME） is a gene marker of leukemia,which can be used to monitor the minimal residual disease,and can make us to comprehend the curative effect,prognosis,the grade of risk and can predict relapse.In addition,PRAME as a human tumour antigen,can be recognized by autologous cytolytic T lymphocytes,is a ideal target of immunotherapy in leukemia,and investigate the methylation level of PRAME gene CpG island,which can help us comprehend the relation of the mechanism of PRAME and leukemia.
出处
《国际儿科学杂志》
2010年第4期352-354,共3页
International Journal of Pediatrics
基金
基金项目：2009年陕西科学技术研究发展计划项目（2009K12-02）
