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自身免疫性淋巴细胞增生综合征研究进展 被引量：1

Progress of autoimmune lymphoproliferactive syndrome
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摘要 自身免疫性淋巴细胞增生综合征是一种由于基因突变影响淋巴细胞程序性死亡或凋亡导致淋巴细胞自身稳定和正常免疫耐受障碍的罕见疾病.临床以淋巴细胞增生、自身免疫性疾病、恶性肿瘤为主要表现.此病发病机制和临床特点复杂,国内目前对此病了解甚少,易造成漏诊误诊,国内尚无此病个案报道. Autoimmune lymphoproliferactive syndrome is a rare group disorders associated with self stability and immune tolerance of lymphocyte due to genetic mutation which affects the lymphocyte apoptosis .The clinical manifestations comprise lymphoproliferation, development of autoimmunity and malignancies.The pathogenesis and clinical features are complex ALPS were easily missed and no case had been reported until now in China.
作者 程真莉(综述) 赵晓东(审校)
机构地区 重庆医科大学附属儿童医院
出处 《国际儿科学杂志》 2010年第4期365-367,371,共4页 International Journal of Pediatrics
关键词 自身免疫性 调亡 FAS基因 双阴性T细胞 Autoimmunity Apoptosis FAS gene Double negative T cell
分类号 R593.2 [医药卫生—内科学]
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参考文献17

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同被引文献13

  • 1胡坚.原发性免疫缺陷病与自身免疫现象[J].实用儿科临床杂志,2007,22(21):1605-1607. 被引量：9
  • 2Al-Herz W,Bousfiha A,Casanova JL,et al.Primary immunodeficiency diseases:an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency[J].Front Immunol,2014,5:162-194.
  • 3Shah S,Wu E,Rao VK,et al.Autoimmune lymphoproliferative syndrome:an update and review of the literatur[J].Curr Allergy Asthma Rep,2014,14:462-465.
  • 4Aude MC,Marie-Claude S,Maria SL.FAS-L,IL-10,and doublenegative CD4-CD8-TCRαβ + T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function[J].Blood,2009,113:3027-3030.
  • 5Rao VK,Dugan Date JK,et al.Use of mycophenolate mofetil for chronic,refractory immune cytopenias in children with autoimmune lymphoproliferative syndrome[J].Br J Haemato,2005,129:534-538.
  • 6Oliveira JB,Bleesing JJ,Dianzani U,et al.Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS):report from the 2009 NIH International Workshop[J].Blood,2010,116:e35-40.
  • 7Poppema S,Maggio E,van den Berg A.Development of lymphoma in autoimmune lymphoproliferative syndrome (ALPS) and its relationship to Fas gene mutations[J].Leuk Lymphoma,2004,45:423-431.
  • 8Rao VK,Oliveira JB.How I treat autoimmune lymphoproliferative syndrome[J].Blood,2011,118:5741-5751.
  • 9Naveed M,Khamis Butt UB,Mannan J.Autoimmune lymphoproliferative syndrome with neonatal onset[J],2014,24:S124-126.
  • 10Teachey DT,Seif AE,Grupp SA,et al.Advances in the management and understanding of autoimmune lymphoproliferative syndrome (ALPS)[J].Br J Haematol,2010,148:205-216.

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国际儿科学杂志
2010年 第4期

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