促肾上腺皮质激素治疗婴儿痉挛症作用机制研究进展

Advance in the ACTH therapeutic mechanisms of infantile spasms

婴儿痉挛症是一种特发于婴儿期的难治性严重癫（癎）性脑病,促肾上腺皮质激素（ACTH）已成为治疗本病的主导药物.但目前对ACTH治疗婴儿痉挛的作用机制仍缺乏合理的解释.研究发现ACTH可能通过负反馈抑制促肾上腺皮质激素释放激素的过度合成和释放,调控神经类固醇、神经生长因子的合成和释放等多种途径发挥疗效.

Infantile spasms is a severe and refractory epileptic encephalopathy that occurs in infancy and early childhood.Adrenocorticotropic hormone （ACTH） has been the major therapy for infantile spasms.However,the ACTH therapeutic mechanisms of infantile spasms still lack relatively reasonal explaination.Recent researches has been found that ACTH might produce its herapeutic effect by suppression of excessive secretion and releasing of corticotrophin releasing hormone,modulation of production and releasing of neurosteroids,neurotrophins,and other putative pathways.