血浆一氧化氮浓度监测与胰腺炎发生多器官功能障碍综合征的关系研究

Nitric oxide involving in the development multipLe organ dysfunction syndrome after severe acute pancreatitis

目的:探索重症急性胰腺炎(SAP)患者血浆一氧化氮浓度与预后的关系,使SAP临床救治获得突破性进展。方法:本试验收集27例确诊为SAP的住院患者,和24例MAP患者形成对照。血浆NO浓度测定采用比色法,分析一氧化氮浓度测定结果。结果:SAP组血浆NO浓度(76.4±34.1)μmol/L,较MAP组(54.8±29.3)μmol/L明显升高(P<0.05)。SAP组发生MODS的患者共10例(占37%),其血浆NO浓度(87.3±41.2)μmol/L较未发生MODS的患者血浆NO浓度(71.2±31.5)μmol/L亦明显升高(P<0.05)。结论:SAP时较MAP产生更大量NO,易致多器官功能障碍。血浆NO测定结果的大小可作为诊断SAP参考依据之一,还可作为判断SAP病情变化、治疗效果及其预后的指标。

Objective In this vestigate,the relationship between the concentration of plasma Nitic Oxide（NO）and prognosis of Severe Acute Pancreatitis was explored,which might be useful for clinical treatment.Methods Patients enrolled in this investigation were inpatients.27cases were with SAP,while 24 Mild Acute Pancreatitis cases were grouped into control group.The plasma levels of NO were measured by colorimetric assay method.we analysed the results.Results The concentration of plasma NO in SAP group（76.4±34.1）μmol/L was signi- ficantly higher than that of control MAP group（54.8±29.3）μmol/L.In SAP group,MODS occurred in 10 cases.The concentration of plasma NO in patients with MODS（87.3±41.2）μmol/L were significantly higher than that in cases without MODS（P0.05）.Conclusion In this investigation,it was suggested that the concentration of plasma NO be one of the useful signs for SAPdiagnosis and prognosis.