甲型H1N1流感大流行的机遇与挑战
摘要
自2009年4月北美首次发现甲型H1N1流感病毒以来，该新型猪源病毒已播散至全球，引起21世纪首次流感大流行，对人类健康产生巨大威胁。与季节性流感不同，本次甲型H1N1流感大流行是由一种整合了古典猪流感、欧亚猪流感、禽流感和人季节性H3N2流感病毒基因的新型四源重组毒株引起。
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2010年第8期561-563,共3页
Chinese Journal of Pediatrics
基金
国家自然科学基金（30973235）
参考文献28
-
1Dawood FS,Jain S,Finelli L,et al.Emergence of a novel swine-origin influenza A(H1N1) virus in humans.N Engl J Med,2009,360:2605-2615.
-
2Fraser C,Donnelly CA,Cauchemez S,et al.Pandemic potential of a strain of influenza A(H1N1):early findings.Science,2009,324:1557-1561.
-
3Siren J,Sareneva T,Pirhonen J,et al.Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages.J Gen Virol,2004,85:2357-2364.
-
4Draghi M,Pashine A,Sanjanwala B,et al.NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection.J Immunol,2007,178:2688-2698.
-
5Mao H,Tu W,Qin G,et al.Influenza virus directly infects human natural killer cells and induces cell apoptosis.J Virol,2009,83:9215-9222.
-
6Guo H,Kumar P,Moran TM,et al.The functional impairment of natural killer cells during influenza virus infection.Immunol Cell Biol,2009,87:579-589.
-
7Mao H,Tu W,Liu Y,et al.Inhibition of human natural killer cell activity by influenza virions and hemagghtinin.J Virol,2010,84:4148-4157.
-
8涂文伟,毛华伟,刘宇隆.机体抗流感病毒免疫应答机制及研究进展[J].中华儿科杂志,2007,45(11):831-834. 被引量：2
-
9O'Riordan S,Barton M,Yau Y,et al.Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza.CMAJ,182:39-44.
-
10Hancock K,Veguilla V,Lu X,et al.Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus.N Engl J Med,2009,361:1945-1952.
二级参考文献42
-
1Hsieh SM, Chang SC. Insufficient perforin expression in CD8 + T cells in response to hemagglutinin from avian influenza (H5N1) virus. J Immunol,2006,176 :4530-4533.
-
2Moskophidis D, Kioussis D. Contribution of virus-specific CD8 + cytotoxic T cells to virus clearance or pathologic manifestations of influenza virus infection in a T cell receptor transgenic mouse model. J Exp Med, 1998,188:223-232.
-
3Belz GT, Wodarz D, Diaz G, et al. Compromised influenza virusspecific CD8 ( + )-T-cell memory in CD4 ( + )-T-cell-deficient mice. J Virol,2002,76:12388-12393.
-
4Swain SL, Dutton RW, Woodland DL. T cell responses to influenza virus infection: effector and memory ceils. Viral Immunol, 2004,17 : 197-209.
-
5Crowe JE,Sannella EC,Pfeiffer S, et al. CD154 regulates primate humoral immunity to influenza. Am J Transplant, 2003,3 : 680- 688.
-
6Gocnik M, Fislova T, Sladkova T,et al. Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection. J Gen Viro1,2007 ,88 :951-955.
-
7Sylte M J, Hubby B, Suarez DL. Influenza neuraminidase antibodies provide partial protection for chickens against high pathogenic avian influenza infection. Vaccine ,2007,25:3763-3772.
-
8Tompkins SM, Zhao ZS, Lo CY, et al. Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1. Emerg Infect Dis,2007,13:426-435.
-
9Simmons CP, Bemasconi NL, Suguitan AL, et al. Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. Plos Med,2007,4:e178.
-
10Kang I, Hong MS, Nolasco H, et al. Age-associated change in the frequency of memory CD4 + T cells impairs long term CD4 + T cell responses to influenza vaccine. J Immunol, 2004, 173 : 673- 681.
-
1印科学家发现3个非典病毒基因[J].现代中西医结合杂志,2004,13(4):449-449.
-
2第14次欧亚神经外科会议信息[J].中国微侵袭神经外科杂志,2007,12(2):75-75.
-
3欧亚眼科大会2003延期召开[J].中华眼科杂志,2003,39(7):388-388.
-
4欧亚眼科大会2003延期通知[J].中华眼科杂志,2003,39(6):370-370.
-
5第三届欧亚眼科大会[J].中国实用眼科杂志,2005,23(2).
-
6第14次欧亚神经外科会议[J].中华老年心脑血管病杂志,2007,9(3):195-195.
-
7第14次欧亚神经外科会议信息[J].中国微侵袭神经外科杂志,2007,12(3):141-141.
-
8第14届欧亚神经外科会议征文通知[J].中国现代神经疾病杂志,2007,7(4):368-368.
-
9卫生部办公厅关于做好应对甲型H1N1流感大流行医疗救治准备工作的通知[J].中国实用乡村医生杂志,2009(10):3-5.
-
10世卫组织：目前仍然无法估计H1N1流感造成的实际死亡人数[J].中医药国际参考,2012(7):30-30.
