摘要
脉冲制剂致力于在疾病治疗需要的给药点定时定量的释放药物,而且可以避免患者在夜间服药或频繁服药,增加了患者的用药顺应性。本文主要介绍了3种可以自身触发的脉冲给药系统,它们不依赖外界化学触发因素,按照其触发机制分类,可分为以下几种,体系降解形成的脉冲释药,膨胀压形成的脉冲释药,体系降解和膨胀压共同形成的脉冲释药系统。本文就该种脉冲制剂的制备工艺、释放机制及影响因素做了分析和总结。自身触发的脉冲给药系统,其定时效果可以根据治疗目的进行调整,尤其是体系降解和膨胀压双重作用的脉冲制剂,有着广阔的发展前景。
Pulsed drug delivery（PDD）,which can be released at well-defined time points as the therapy needs,can decrease the frequency and avoid taking drug at night,thus improving patient compliance.Here we introduce three kinds of programmed PDD systems independent of external chemical triggering;they are divided according to the triggering mechanisms：degradation-triggered PDD,osmotic pressure-triggered PDD,and both degradationi and osmotic pressure-triggered PDD.This paper reviews preparing technique,release mechanisms and influencing factors of the three PDD systems.The release profiles of pulsatile PDD can be regulated for different therapeutic needs,requiring no external triggers;especially that the PDD system triggered by both degradation and osmotic pressure has a bright future.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2010年第7期782-786,共5页
Academic Journal of Second Military Medical University
关键词
药物脉冲疗法
脉冲释放
体系降解
膨胀压
drug pulse therapy
pulsed drug release
degradation
osmotic pressure
