微波辐射固相合成5-(取代吲哚基-3-次甲基)(硫代)巴比妥酸

Solid State Synthesis of 5-(Substituted indole-3-ylmethylidene)(Thio) Barbituric Acid under Microwave Irradiation

在无溶剂、无催化剂、微波辐射条件下,取代吲哚-3-甲醛与(硫代)巴比妥酸通过Knoevenagel缩合反应,合成了一系列5-(取代吲哚基-3-次甲基)(硫代)巴比妥酸。最佳反应条件为:n(吲哚-3-甲醛)∶n(巴比妥酸)=1.2∶1.0,微波辐射时间8 min,微波功率500 W,产率68.4%～82.8%。

A series of 5-（substituted indole-3-methylidyne）（thio） barbituric acids were synthesized by Knoevenagel condensation between substituted indole-3-formaldehyde and barbituric acid or thiobarbituric acid under microwave irradiation without solvent and catalyst.The optimum reaction conditions were as follows： the power of microwave was 500 W;the time of irradiation was 8 min; n（substituted indole-3-tormaldehyde）∶n（barbituric acid） was 1.2∶1.0.The yield was 68.4%～82.8%.