近期感染与脑梗塞关系初探

The Relationship between Recent Infection and Cerebral Infarction

目的：探讨近期感染与脑梗塞间的关系。方法：采用前瞻性的病例对照研究方法对１４５例急性脑梗塞患者及年龄、性别、居住地与脑梗塞患者相匹配的因非感染性疾病在我院住院患者中随机选择１４５例对照者进行研究。结果：脑梗塞患者病前１周内的感染明显高于对照者（Ｐ＜００１）；病毒感染与细菌感染同样增加了脑梗塞的危险；近期感染增加了各年龄组脑梗塞的危险；进行多元条件下ｌｏｇｉｓｔｉｃ回归发现，近期感染是脑梗塞有意义的独立的危险因素（ＯＲ，４６；９５％ＣＩ２２～８５４）。结论：近期感染是各年龄组脑梗塞重要的独立的危险因素之一。

Objective:The aim of this study was to investigate the relationship between recent infection and cerebral infarction.Methods:A prospective case-control study was carnied out with 145 patients,aged 33 to 82 years,with acute cerebral infarction and 145 randomly selected hospitalized patients from noninflammatory diseases matched in pairs for sex,age,and area of residence were served as control.Results:Infection within 1 week before ictus was significantly more common among patients with cerebral infarction than that of the controls( P <0 01).Infection in the preceding week was a factor of risk for cerebral infaction(odds ratio OR 4 4;95% confidence interval(CI),2 6 to 6 34).Both viral and bacterial infections would increase the risk.Recent infection increased the risk for cerebral infarction in all age groups and remained a significant risk factor when other vascular risk factor were included as covariance in a logistic regression(OR,4 6;95% CI,2 2 to 8 54).Conclusions:Recent infection is an important and independent risk factor for cerebral infarction in all age groups.