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mTOR通路激活在动脉粥样硬化发生中的作用 被引量：4

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摘要 雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是哺乳类动物细胞表达的一种丝氨酸/苏氨酸蛋白激酶。近年研究发现,mTOR通路激活以直接或间接的方式参与了动脉粥样硬化(AS)的发生机制,与炎症反应、脂代谢紊乱在致AS中可能存在协同作用。该文主要从mTOR通路的组成及生理调控机制,炎症、脂代谢紊乱对mTOR通路激活的影响,以及mTOR激活在炎症、脂代谢紊乱促泡沫细胞形成中的作用等几个方面加以综述,旨在对mTOR在AS中作用机制的了解,为临床上防治AS提供新思路。
作者 刘晶 马坤岭 刘必成
机构地区 南京东南大学附属中大医院肾脏病研究所
出处 《国际心血管病杂志》 2010年第4期197-199,共3页 International Journal of Cardiovascular Disease
基金 江苏省自然科学基金(BK2009279)
关键词 动脉粥样硬化 炎症 雷帕霉素靶蛋白 脂代谢紊乱
分类号 R543 [医药卫生—心血管疾病]
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共引文献50

同被引文献18

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引证文献4

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国际心血管病杂志
2010年 第4期

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