小儿哮喘微型灌肠剂制备工艺研究

Study on Preparation Procedure for Xiaoerxiaochuan Microenema

将小儿哮喘方按传统煎煮法、水提醇沉法、水提醇沉分步提取法制成了工艺ａ、工艺ｂ、工艺ｃ３种药液。以处方中主药麻黄所含有的麻黄碱（Ｅ）、伪麻黄碱（ＰＥ）作为定量指标，以药液抗慢反应性物质（ＳＲＳＡ）作用作为药效学指标，比较３种不同制备工艺的药液。根据上述实验结果和制剂成型的可行性。

The Xiaoerxiaochuan Prescription was extracted by the methods of traditional decoction, water extraction and alcohol precipitation and fractional extraction with water extraction and alcohol precipitation, respectively. And three kinds of extract solution: procedure A, procedure B and procedure C were prepared. The three kinds of extract solution were compared in ephedrine and pseudoephedrine containes by the main Chinese materia medica: Herba Ephedrae of prescription as the quantitative indexes, and the anti slow reation substance (SRS A) action of extract solution as the pharmacodynamic index. According to the experimental result and ability of preparation formation, procedure C was choosed as a procedure for microenema preparation.