干地黄提取物A、B抗大鼠实验性胃溃疡作用

Effects of extract A or B of the dry radix rehmanniae (DRR) on resisting experimental gastric mucosal ulcers

目的 研究干地黄提取物A、B对大鼠急、慢性实验性胃溃疡的影响及可能机制。方法 用 80 %的乙醇将干地黄煎剂分成A(醇溶性部分 )、B(醇不溶性部分 )两大部分 ,采用无水乙醇型和慢性乙酸型胃溃疡模型进行观察。结果 ①预先胃饲 12g/kg提取物A或B ,均能显著抑制无水乙醇所致的胃粘膜损伤 ,抑制率分别为 98 7%和 61 0 % ;②每天胃饲 6或 12g/kgA提取物还能加快无水乙醇型和慢性乙酸型胃溃疡的愈合 ;③肌注 12g/kgA提取物对无水乙醇性胃粘膜损伤无明显影响 ,胃饲 6g/kgA提取物对胃壁结合粘液量也没有影响。结论 干地黄既能预防溃疡的形成 ,又能促进溃疡的愈合 ;其活性成份主要位于醇溶性部分 。

Objective To study the effects and its possible mechanism of the dry radix rehmanniae(DRR) extracts on acute and chronic experimental gastric ulcer.Methods The DRR decoction was divided into A(section which dissolved in ethanol) and B(undissolvable section) by 80% ethanol. The absolute ethanol-induced gastric mucosal damage model and the chronic acetate-induced gastric ulcer one were used.Results ①The 12 g/kg extract A or B given orally in advance both inhibited markedly gastric mucosal damage induced by ethanol in the inhibitory rates of 98.7% and 61.0% respectively. ②The 6 or 12 g/kg extract A given orally promoted markedly recovery from ethanol-induced damage and acetate-induced ulcer also. ③The 12 g/kg extract A injected intramuscularly could not reduce markedly damage induced by ethanol and the 6 g/kg one had no effect on the volume of gastric binding mucus too.Conclusion The DRR can prevent the formation of the damage or ulcer and promote the recovery from ones. The greater part of its effective components exist in the section which dissolves in ethanol. The action of it may be not mediated by the absorption of active ingredients and gastric mucus secretion.