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肺癌患者CD4^+CD25^+调节性T细胞的检测及临床意义 被引量:5

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摘要 目的探讨肺癌患者外周血中CD4+CD25+调节性T细胞的变化及意义。方法采用流式细胞技术检测60例肺癌患者外周血中CD4+CD25+调节性T细胞,采用ELISA法检测外周血中转化生长因子-1(TGF-1)的表达水平。结果肺癌患者外周血中CD4+CD25+调节性T细胞占T淋巴细胞的百分比为(6.46±0.42)%,与对照组(3.40±0.80)%比较差异有显著性(<0.05)。30例鳞癌、17例腺癌、13例小细胞癌患者外周血中CD4+CD25+调节性T细胞比例分别为(6.51±0.37)%、(6.23±0.50)%、(6.65±0.89)%,各组间比较差异无显著性(>0.05);均显著高于对照组(3.40±0.80)%(<0.05);22例Ⅲ期,29例Ⅳ期肺癌患者外周血中CD4+CD25+调节性T细胞比例为(6.13±0.45)%,(7.16±0.50)%,均显著高于9例Ⅱ期患者(5.02±0.62)%(均<0.05)。肺癌患者外周血中CD4+CD25+T细胞水平与TGF-1相关性不强(=0.265),与CD8+CD28+T细胞呈负相关(=—0.531)。结论肺癌患者外周血中具有免疫抑制活性的CD4+CD25+调节性T细胞水平较高,且与分期有关,对肺癌患者具有免疫抑制作用。
机构地区 浙江省台州医院
出处 《现代实用医学》 2009年第11期1215-1216,共2页 Modern Practical Medicine
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参考文献10

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二级参考文献12

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