经输血传播病毒的前瞻性调查

Prospective study of TTV transmission by blood transfusion

目的了解我国供血员、受血者中经输血传播病毒（ＴＴＶ）感染率，及经输血传播ＴＴＶ的发生率。方法对１３０例输血者进行ＴＴＶ以及ＨＢＶ和ＨＣＶ血清标志物检测，其相应的供血者也检查ＴＴＶ。结果３４０例供血员中有３６例（１０．６％）可检测到ＴＴＶ－ＤＮＡ。１３０例受血者输血前有１１例（８．５％）ＴＴＶ阳性，其余１１９例输血后有１８例ＴＴＶ转为阳性，在他们的供血中至少可查到一份ＴＴＶ阳性。４６例输血后肝炎病毒感染者中，其中有４５例为ＨＣＶ感染（包括７例与ＴＴＶ混合感染），２例为ＨＢＶ感染（包括与ＨＣＶ、ＴＴＶ混合感染各１例）。ＴＴＶ与ＨＢＶ混合感染以及７例ＴＴＶ与ＨＣＶ混合感染中有３例的受血者ＡＬＴ＞９０Ｕ／Ｌ，但是１０例单纯ＴＴＶ感染者，仅有２例伴有轻微的ＡＬＴ增高。结论供血员及住院病人中有较高的ＴＴＶ感染率，单纯ＴＴＶ感染与ＡＬＴ显著升高似乎并无关联。

Objective To investigate the prevalence of transfusion-transmitted virus (TTV) in blood donors and recipients and theincidence of TFV transmission by blood transfusion. Methods TTV DNA and serum markers of hepatitis B virus (HBV), hepatitis Cvirus (HCV) were detected in 130 blood recipients, and TTV was also detected in their 340 corresponding blood donors. Results Theprevalence of TTV infection was 10.6% (36/340) in the donors, and 8.5% (if/130) in the recipients before transfusion. Eighteenpatients (15. 1%) were found to be TTV positive de transfusion in the 119 blood recipients without TTV before, at least one of thecorresponding donors was found to positive for TTV There were 46 cases of post-transfusion hepatitis virus infection, 45 of thembeing HCV infection (including 7 cases co-infected with TTV) and 2 HBV infections (including 1 co-infection with HCV and 1 withTTV). The recipient with TTV and HBV co-infection and 3 of the 7 cases with both TTV and HCV infection had a ALT level higherthan 90 U/L, but only 2 cases of the 10 isolated TTV infection had a mild ALT elevation. Conclusions The prevalence of TTV israther high in blood donors, hospitalized patients and isolated TTV infection seems not related with significant ALT elevation.