血管内皮生长因子和微血管密度与乳腺浸润性导管癌生物学行为的关系

Expression of vascular endothelial growth factor and microvessel density in mammary infitrating ductal carcinoma and its relationship with biological behaviour

目的探讨血管内皮生长因子和微血管密度与乳腺浸润性导管癌生物学行为的关系。方法应用免疫组化方法检测55例术前未作过化疗的乳腺浸润性导管癌组织中血管内皮生长因子(VEGF)、微血管密度(MVD)的表达,与乳腺癌的临床分期、淋巴结转移等生物学行为进行统计学分析。结果 (1)乳腺浸润性导管癌组织中MVD值与淋巴结转移、临床分期密切相关(P<0.05);(2)VEGF主要表达于肿瘤细胞胞浆或胞膜,与乳腺浸润性导管癌淋巴结转移、临床分期有关(P<0.05);(3)乳腺浸润性导管癌VEGF表达与MVD值密切相关(P<0.05)。结论 VEGF表达与乳腺浸润性导管癌的血管生成和侵袭转移关系密切。MVD和VEGF的检测可以用于乳腺浸润性导管癌的预后判断。

Objective To study the expression of vascular endothelial growth factor（VEGF） and microvessel density（MVD） in mammary infitrating ductal carcinoma and its relationship with biological behaviour.Methods Speciece of mammary infitrating ductal carcinoma were detected the expression of VEGF and MVD by immunohistochemical methods.MVD was calculated according to the quantification of positive Ⅷ factor expression.Clinicopathological characteristics of the patients includingtumor size,clinical stage and auxiliary lymph node metastasis were recorded and compared with the results of VEGF and MVD expression.Results VEGF expression and MVD in invasive breast cancer group were greater than those in normal control group.VEGF expression and MVD were correlated to clinical stage.VEGF expression and MVD in invasive breast cancer with lymph node metastasis were significantly higher than those without lymph node metastasis.MVD was correlated with VEGF expression.Conclusion MVD and expression of VEGF are correlated to vessel formation and invasion of invasive breast cancer.MVD and expression of VEGF may provide reference for prognostic evaluation of invasive breast cancer.