超敏C反应蛋白和血管性假性血友病因子对高血压合并颈动脉粥样硬化的诊断价值

Diagnostic value of high-sensitivity C-reactive protein(hs-CRP) and von Willebrand factor(vWF) in carotid atherosclerosis in essential hypertension patients

目的研究血清超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)和血管性假性血友病因子(vonWillebrand factor,vWF)与高血压患者合并颈动脉粥样硬化发生的关系。方法对入选的148例高血压患者进行颈动脉超声检查测量颈总动脉内膜中层厚度(IMT)、观察有无斑块形成,并分为颈动脉正常组(42例)、颈动脉增厚组(83例)和颈动脉斑块组(23例),分别检测血清超敏C反应蛋白、假性血友病因子和血脂指标,进行组间比较。并把hsCRP、vWF分别与年龄、收缩压、脉压和高血压危险度分层进行相关性分析。结果 hsCRP在颈动脉正常组与颈动脉斑块组间有显著差异(P<0.01);vWF在颈动脉正常组与颈动脉斑块组间有显著差异(P<0.05)。hsCRP与年龄有显著性相关,vWF与年龄、脉压和高血压危险度有相关性。hsCRP与vWF具有相关性。结论 hsCRP和vWF都与动脉粥样硬化的发生相关。

Objective To study the relationship between high-sensitivity C-reactive protein（hs-CRP） / von Willebrand factor（vWF） and carotid atherosclerosis in essential hypertension patients.Methods With the help of ultrasound,83 cases of increased intima-media thickness of carotid artery,23 of atheromatous plaque formation and 42 of normal arteries were noted in 148 cases of essential hypertension.Serum hs-CRP,vWF and blood lipid were examined in these cases and analysed together with the factors of age,systolic pressure and hypertension criticality.Results In comparison with the normal carotid artery group,serum hs-CRP（P〈0.01） and vWF（P〈0.05）were significantly higher in the arteriosclerosis group,whilst hs-CRP was correlated with age and vWF with age,systolic pressure and hypertension criticality.Conclusion Serum hs-CRP and vWF are associated with carotid atherosclerosis.