德诺低剂量三联疗法治疗幽门螺杆菌胃炎的观察

Experimental Studies on Nitric Oxide Induced Membrane Lipid Peroxidation in Viral Myocarditis

应用德诺三联用药（低剂量三联疗法）治疗幽门螺杆菌（ＨＰ）阳性慢性胃炎患者。４１例ＨＰ阳性病人３种药物（ＤｅＮｏｌ２４０ｍｇ，甲硝唑０４，阿莫西林０５）于早晚餐后服用，共服１４ｄ，ＨＰ根除率为８７７０％，慢性炎好转率为６０９８％，活动性炎好转及消失率分别为６５８５％，１７０７％；慢性胃炎伴肠上皮化生２６例，肠化生减轻和消失１１例，占４２３１％。

To investigate the relationship between nitric oxide and membrane lipid peroxidation in viral myocarditis,we used the murine model of Coxsakievirus B 3 induced myocarditis (four week old Balb/c male mice were inoculated intraperitoneally with 5×10 3 PFU Coxsakievirus B 3 in 0 3 ml fetal bovine serum),then divided them to two groups randomly 0 05 mg L arginine in 1 ml drinking water was given to each mouse in the first group p o twice a day The second group was only given drinking water The result showed the level of nitric oxide in the first group was significantly higer than that in the second group(53 17±8 80,30 80±8 60, P <0 01) So was the level of MDA(12 30±1 80,9 90±1 60, P <0 01),but the SOD activity in the first group was much lower than that in the second group(64 30±12 80,79 80±14 20, P <0 01) Histologically,the degree of myocardial damage in the first group was more serious than that in the second group Therefore,nitric oxide may aggravate membrane lipid peroxidation and exacerbate myocardial damage in viral myocarditis