摘要
为了探索病毒性心肌炎中一氧化氮（ＮＯ）和脂质过氧化作用的关系，应用柯萨奇病毒Ｂ３诱导的小鼠病毒性心肌炎模型进行研究（将滴度为５×１０３ＰＦＵ的ＣＶＢ３病毒接种到小鼠腹腔内），然后随机将其分为两组：第１组每ｄ用５％Ｌ精氨酸１ｍｌ灌胃２次，第２组正常饮水。结果表明：第１组ＮＯ水平显著高于第２组（５３１７±８８０，３０８０±８６０，Ｐ＜００１）；第１组ＭＤＡ较第２组明显升高（１２３０±１８０，９９０±１６０，Ｐ＜００１）；而超氧化物歧化酶活性第１组较第２组显著降低（６４３０±１２８０，７９８０±１４２０，Ｐ＜００１）；组织病理学检查发现，第１组心肌病变程度明显重于第２组。提示：ＮＯ在病毒性心肌炎中具有促进脂质过氧化作用，从而加重对心肌的损害。
Enalapril,an ACEI,was used in the
treatment of 40 patients with grade Ⅰ～Ⅱ primary hypertention,5～20 mg/d for 3 months
Clinical manefestations and ultrasonic cardiographic indices were observed The results
showed that Enalapril had effects of effectively controlling blood pressure while not affecting
heart rate,reversing left ventricular hypertrophy,reducing left ventricular mass and improving
the function of cardic contraction and relaxation It is suggested that Enalapril is a satisfactory
agent in the treatment of grade Ⅰ～Ⅱ primary hypertention
