庚型肝炎病毒感染研究

Study on Hepatitis G Virus infection

目的 了解山东省HGV感染状况,探讨HGV感染与HCV或HBV感染的关系。方法 应用酶联免疫吸附试验(ELISA)对1082例病毒性肝炎患者、77例非甲至戊型肝炎患者和361名献血员进行了血清抗-HGV检测。结果 共检出血清抗-HGV阳性者53例,阳性率3.49%。丙型肝炎患者血清抗-HGV阳性率(8.93%)显著高于乙型肝炎患者(3.32%)(χ2=8.80,P<0.01)。慢性肝炎患者血清抗-HGV阳性率(4.82%)显著高于急性肝炎患者(0.79%)(χ2=10.79,P<0.01)。重型肝炎患者血清抗-HGV阳性率(8.00%)显著高于急性肝炎患者(χ2=10.23,P<0.01)。结论 HGV感染可表现为病毒携带状态、亚临床型和不同临床类型,丙型肝炎患者较乙型肝炎患者更易重叠感染HGV。

Objective To find out the situation of HGV infection in Shandong Province, and to explore the relations between HGV infection and HCV or HBV infection.Methods Enzyme linked immunosorbent assay (ELISA) was used to determine the serum anti-HGV in 1 082 patients with viral hepatitis, 77 patients with non A-E hepatitis and 361 blood donors. Results 53 patients whose serum anti-HGVs were positive (positive rate: 3.49 %) were noticed. The anti-HGV positive rate ( 8.93 %) in patients with Hepatitis C was remarkably higher than that ( 3.32 %) in patients with Hepatitis B (χ 2= 8.80 , P <0.01). The anti-HGV positive rate ( 4.82 %) in patients with chronic hepatitis was significantly higher than that ( 0.79 %) in patients with acute hepatitis (χ 2= 10.79 , P < 0.01 ). The anti-HGV positive rate (8.00%) in patients with severe hepatitis was obviously higher than that in patients with acute hepatitis (χ 2= 10.23 , P < 0.01 ).Conclusion The manifestations of HGV infection can be expressed as virus-carriers, subclinical infection or various clinical types. Patients with Hepatitis C were more subjective to be overlapped with HGV than the patients with Hepatitis B; moreover, HCV or HBV infection superinfected with HGV is associated with exacerbation of patients' condition and the formation of chronic infection.