血清淀粉样蛋白A1基因多态性与血清高密度脂蛋白胆固醇水平的关系

Association of genetic polymorphisms of serum amyloid protein A1 with plasma high density lipoproteins cholesterol

目的 探讨血清淀粉样蛋白A1（SAA1）基因多态性对血清高密度脂蛋白胆固醇（HDL-C）水平的影响.方法 资料来源于2007年6月至2009年3月对新疆自治区不同民族心血管疾病危险因素调查研究数据,入选健康汉族人607人,采用限制性片段长度多态性的方法对SAA基因288T〉C（rs12218）进行分型.血脂水平检测由新疆医科大学第一附属医院检验中心统一测定.结果 rsl2218基因型之间HDL-C水平差异有统计学意义（F=3.461,P=0.032）;CC基因型携带者HDL-C水平明显低于Tr基因型[（1.28±0.38）mmol/L比（1.44 4-0.43）mmol/L,P=0.017];在校正性别和年龄等影响因素后,CC基因型携带者HDL-C水平仍然低于1111rI.II基因型者[（1.27±0.07）mmol/L比（1.41±0.03）mmol/L,P=0.048].结论 在新疆汉族人群,SAA1基因288T〉C多态性对HDL-C的水平有明显影响,CC基因型HDL-C水平明显低.

Objective To explore the association of genetic polymorphism （rsl2218） of serum amyloid protein Al （SAA1） with serum high density lipoproteins cholesterol （HDL-C）. Methods A total of 607 healthy subjects were recruited into the Cardiovascular Risk Survey between June 2007 and March 2009. Their genotypes of SAA1 were detected by polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP）. Results There was no significant difference between each genotype of SAA1 in triglyceride, total cholesterol and low density lipoprotein cholesterol （ LDL-C）. But marked significance existed between CC genotype and TT genotype in serum HDL-C level both before[ （1. 28 ±0. 38） mmol/L vs （1.44±0.43） mmol/L, P = 0.017] and after adjusting for gender and age [（1.27 ±0.07） mmol/L vs （1.41 ±0.03） mmol/L, P=0.048]. Conclusion In Chinese Han people, the genetic polymorphism of SAA1 may reflect the serum concentration of HDL-C. The carriers with CC genotype have a lower HDL-C level.