摘要
目的：研究铁屎米酮对心肌缺血再灌注损伤的保护作用。方法：大鼠左冠脉前降支结扎造成心肌缺血再灌注损伤。结果：铁屎米酮（５，１０及２０ｍｇ·ｋｇ－１，ｉｇ）可显著降低缺血再灌性心律失常发生率，缩短心律失常持续时间，防止室颤的发生；减少心肌丙二醛含量，提高心肌超氧物歧化酶活性；减轻心肌细胞超微结构损伤。
AIM: To study the effect of canthin 6 one (Can) on myocardial ischemia and reperfusion injury. METHODS: The left coronary artery of the rat was ligated. RESULTS: Can (5, 10, 20 mg·kg -1 , ig) was shown to decrease the incidence of arrhythmia induced by ischemia and reperfusion, shorten the duration of ventricular arrhythmia, eliminate the incidence of ventricular fibrillation; increase the activities of superoxide dismutase (SOD), decrease the malondialdehyde (MDA) contents and alleviate the myocardial ultrastructure injury. CONCLUSION: Can has protective effect on the injury induced by myocardial ischemia and reperfusion.
出处
《药学学报》
CAS
CSCD
北大核心
1999年第3期161-163,共3页
Acta Pharmaceutica Sinica
基金
中国科学院资源与环境研究"九五"重大项目"治疗数种重要疾病新天然药物的研究与开发"专题基金
关键词
铁屎米酮
再灌注损伤
心肌缺血
心肌保护
大鼠
canthin 6 one
myocardial reperfusion injury
arrhythmia
superoxide dismutase
