摘要
目的:探讨IL-2R与鼻咽癌发生、发展的关系。方法:应用间接免疫荧光法和ELISA法对62例鼻咽癌、21例鼻咽良性病变和26例健康对照者外周血单个核细胞(PBMC)经植物血凝素(PHA)刺激后的mIL-2R和血清sIL-2R水平进行检测。结果:1)鼻咽癌患者mIL-2R表达显著低于鼻咽良性病变和健康对照组(P<0.05);2)鼻咽癌患者血清sIL-2R水平显著高于鼻咽良性病变和健康对照组(P<0.01);3)与无远处转移的鼻咽癌患者相比,有远处转移的鼻咽癌患者血清sIL-2R显著升高(P<0.01);4)鼻咽良性病变与健康对照组之间mIL-2R表达和sIL-2R水平无显著差异。结论:结果提示mIL-2R表达低下和sIL-2R异常升高在鼻咽癌患者机体免疫抑制中可能起重要作用。
Objective: To study the relationship between the expression of IL-2R and the development of nasopharyngeal carcinoma. Methods: mIL-2R and serum sIL-2R were detected in patients with nasopharyngeal carcinoma, benign nasopharyngeal diseases and health control. Results: Significantly lower level ( P <0.05) of mIL-2R and significantly higher level ( P <0.01) of sIL-2R were found in nasopharyngeal carcinoma than in benign nasopharyngeal diseases and in health control. The expression of sIL-2R was significantly higher ( P <0.01) in patients with nasopharyngeal carcinoma with metastases than without metastases. No obvious difference of mIL-2R or sIL-2R was found between benign nasopharyngeal diseases and health control. Conclusion: The down regulation of mIL-2R expression as well as the abnormal increase in sIL-2R may play a role in the immunodepression from nasopharyngeal carcinoma.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
1999年第1期6-8,共3页
Chinese Journal of Otorhinolaryngology-skull Base Surgery