通心络胶囊在不稳定型心绞痛患者介入治疗中的作用

Effects of Tongxinluo Capsules on interventional therapy of patients with unstable angina

目的:探讨通心络胶囊对不稳定型心绞痛患者经皮冠状动脉介入治疗(PCI)过程中的保护作用及可能的机制。方法:选择不稳定型心绞痛患者110例,随机分为通心络胶囊组(57例)和常规治疗组(53例),通心络胶囊组术前给予通心络胶囊治疗7d,术后继续服药0.5年;常规治疗组给予常规药物治疗。两组患者均在PCI术前、术后24h、术后1个月、术后6个月采肘静脉血,检测hs-CRP、IL-6mRNA、内皮素(ET)和内皮依赖性血管舒张功能(FMD)。6个月后再次行CAG检查,了解再狭窄情况及再次冠脉事件的发生率。结果:术后6个月IL-6mRNA表达、hs-CRP、ET较术前降低,通心络胶囊组较常规治疗组显著下降(P<0.01)。hs-CRP的变化与IL-6mRNA表达的变化一致。术后6个月,两组FMD均明显升高,通心络胶囊组升高更明显(P<0.01)。随访期间,通心络胶囊组心绞痛发生率、再次PCI、累计主要不良心脏事件及再狭窄率均较常规治疗组明显降低(P<0.05或P<0.01)。结论:通心络胶囊可明显抑制PCI术后炎症反应,保护、改善内皮功能,从而减少随访期间心绞痛发生率、再次PCI、累计主要不良心脏事件及再狭窄率的发生。

Objective：To investigate the protective effects of Tongxinluo Capsules on interventional therapy of patients with unstable angina.Methods：110 patients with unstable angina were randomly divided into experimental conventional therapy group（53 cases,treated with conventional therapy） and Tongxinluo Capsules group（57 cases,treated with Tongxin luo Capsules for 7 days before operation and continued to administer Tongxinluo Capsules for 0.5 years）.The two groups were collected venous blood at the time of preoperative,24 h after operation,one month after operation,six months after operation.All the patients were determined hs-CRP,IL-6 mRNA,FMD and ET.Six months later,the message of resteno sis and heart incidents were collected.Results：After six months＇ therapy,Tongxinluo Capsules group obviously reduced with the IL-6 mRNA expression,hs-CRP and ET level（P0.01）,and oviously advanced with FMD（P0.01）.The angina incidence rate,PCI again and unhealthy conscience incident were lower（P0.05 or P0.01）.Conclusion：The treatment of Tongxinluo Capsules can refrain inflammatory reaction,protect endodermis function,and reduce unhealthy conscience inci dence.