地屈孕酮与绒毛膜促性腺激素对先兆流产的疗效观察

Observation of curative effect of Dydrogesterone and Chorionic Gonadotrophin in the treatment of threatened abortion

目的:通过观察地屈孕酮和绒毛膜促性腺激素(HCG)对先兆流产的治疗效果,探讨两种药物对妊娠结局的影响。方法:选取门诊诊断为早期先兆流产的孕妇253例,分为三组,A组给予地屈孕酮片10mg口服,2次/d;B组给予HCG2000IU肌内注射,1次/d;C组为对照组,仅予卧床休息。治疗截止日为阴道出血停止后维持用药1周。追踪随访观察对象的妊娠成功率、足月分娩率、流产率、早产率、新生儿畸形率、新生儿并发症、新生儿体重等指标。结果:A组与B组在妊娠成功率及流产率方面差异无统计学意义,但是同C组比较差异均有统计学意义。A组、B组新生儿体重高于C组,差异有统计学意义。三组新生儿畸形率、新生儿并发症比较,差异均无统计学意义。结论:地屈孕酮与HCG均能改善先兆流产患者的预后,且对母儿无不良影响。

Objective：To observe the efficacy of Dydrogesterone and Chorionic Gonadotrophin in the treatment of threatened abortion,and approach the effective of two kinds of medicine in the treatment of pregnancy outcome.Methods：The patients was diagnosed as threatened abortion in early pregnant women 253 cases,divided into 3 groups,Dydrogesterone 10 mg oral tablet,2 times/day for group A;intramuscular injection of HCG 2000 IU,1 times/day for group B;group C was control group,only to be bed rest.The deadline for the treatment was vaginal bleeding 1 week after the cessation of main tenace medication.Followed up the success rate of pregnancy observed objects,full-term delivery rate,miscarriage rate,premature delivery rate,neonatal malformation rate,neonatal complications,neonatal weight and other indicators.Results：The successful pregnancy rate and abortion rate were not significance of difference between group A and group B,but compared with the C group,there were significant differences.The neonatal weight of group A and group B were heavier than group C,the difference was statistically significant.The rate of neonatal malformations and neonatal complications in three groups,there were not statistically significant.Conclusion：Dydrogesterone and HCG can improve the prognosis of threatened abortion,and no adverse effects on mother and child.