精子CYP1A1基因多态性与壮族人群少精症的关系

CYP1A1 gene polymorphism in oligozoospermic infertile patients of Zhuang population in Guangxi area.

目的探讨壮族人群精子CYP1A1基因多态性与少精症的关系。方法应用限制性内切酶消化法对105例壮族少精不育患者(实验组)及140例健康男性(对照组)精子细胞CYP1A1基因进行多态性研究,探讨该基因对少精症的影响。结果实验组的缺失型基因高于对照组,差异有统计学意义(P<0.05)。结论壮族人群精子CYP1A1基因多态性与男性少精症有着较为密切的联系,其具体作用机制有待进一步研究。

Objective To explore the association between CYP1A1 gene polymorphism and oligozoospermia. Methods The PCR -RFLP technique was used to analyze the CYP1A1 gene Polymorphisms in 105 infertile men （the study group） and 140 healthy men （ the control group） of Zhuang population in Guangxi area. Results The mutant genotype was found significantly more frequent in infertile men than in controls. Conclusion The polymorphisms in CYP1A1 may have modulating effects on human spermatogenesis. Further research is required to clarify the mechanism.