急性冠脉综合征血瘀证患者介入治疗围术期炎症介质变化的相关性

Relationship between blood stasis syndrome and inflammatory factors in patients with ACS during perioperative period.

目的探讨急性冠脉综合征患者介入围术期血瘀证与部分炎症因子的相关性,为中医药临床证候基础研究提供科学依据。方法前瞻性调查性研究,采集围术期不同中医证候急性冠脉综合征患者血样,酶联免疫方法测定分析血样中白介素6(IL-6)、白介素8(IL-8),免疫散射比浊法测定超敏C反应蛋白(hs-CRP),采用描述性分析、Logistic回归分析等。结果无论是术后或是术前,血瘀证评分较重的患者其IL-6及IL-8水平均较轻症患者为高,但只有术后IL-6水平与术后血瘀证评分及术前、后IL-8水平与术后血瘀证评分的程度差异有统计学意义(P<0.05)。Logistic回归分析提示术后IL-6水平为术后血瘀证重者的可能影响因素。结论 IL-6、IL-8及hs-CRP水平可能与血瘀证严重程度相关,但相关程度及原因仍需进一步研究。

Objective To study the relationship between blood stasis syndrome and inflammatory factors in patients with ACS during perioperative period of percutaneous coronary intervention （PCI）. Methods Blood specimen and information of traditional Chinese Medicine in patients with ACS were collected before and after PCI. Levels of interleukin 6 （IL- 6）, interleukin 8 （IL- g） and C -reactive protein （CRP） were measured using radioimmunoassay. Descriptive analysis and Logistic regression analysis were used for data analysis. Results Although levels of IL - 6 and IL - 8 were higher in the patients with high blood stasis syndrome score than those with low score, not all the differences were significant. Logistic regression analysis revealed that blood IL - 6 level after PCI correlated with the severity of blood stasis syndrome in patients with ACS. Conclusion Though IL - 6, IL - 8 and CRP may be associated with the severity of blood stasis syndrome, further study is needed.