聚乙二醇对甲苯磺酸酯的制备

Synthesis of polyethylene glycol tosylate

标题化合物是制备多种末端功能化聚乙二醇衍生物的重要中间体。交流不同分子量的聚乙二醇和聚乙二醇单甲醚与对甲苯磺酰氯进行酯化的反应条件及提纯方法,制备出3个双（对甲苯磺酸）聚乙二醇酯,收率65%－80%;2个单对甲苯磺酸聚乙二醇单甲醚酯,收率55%－61%;其结构经1HNMR表征。

Polyethylene glycol tosylate is a useful intermediate for the preparation of the functionalized polyethylene glycol.A series of polyethylene glycol di-tosylates and polyethylene glycol mono-tosylates were synthesized from polyethylene and p-toluenesulfonyl chloride with the yields of products reaching 55%～80%,and the products were characterized by 1HNMR spectrometry.