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生长分化因子-15在心血管疾病中的临床价值 被引量：1

Clinical Value of Growth-differentiation Factor-15 in Cardiovascular Disease
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摘要 生长分化因子-15是转化生长因子-β超家族成员之一,具有抗肿瘤、抗器官损伤等细胞保护功能。生长分化因子-15属于氧化应激蛋白,在损伤心肌中大量表达。最新文献报道,生长分化因子-15对预测心力衰竭、心肌梗死预后有重要作用,现就生长分化因子-15对多种心血管疾病中的预测作用及其临床应用做一综述。 Growth-differentiation factor-15 is a member of the transforming growth factor-β cytokine superfamily.Growth-differentiation factor-15 is an oxidative stress protein that is abundantly expressed in the injured myocardium.The latest literature reports that growth-differentiation factor-15 also has an important role in predicting heart failure and myocardial infarction.This article provides an overview of the ability of growth-differentiation factor-15 to predict cardiovascular disease,and its possible clinical applications.
作者 吴少威 石理
机构地区 暨南大学第三附属医院 珠海市人民医院心内科
出处 《心血管病学进展》 CAS 2010年第4期631-633,共3页 Advances in Cardiovascular Diseases
关键词 生长分化因子-15 心力衰竭 急性冠状动脉综合征 预后 growth-differentiation factor-15 heart failure acute coronary syndrome prognosis
分类号 R54 [医药卫生—心血管疾病]
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参考文献23

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同被引文献19

  • 1Anand IS, Kempf T, Rector TS, et al. Serial measurement of growth-differentiation factor-15 in heart failure: relation to disease severity and prognosis in the Valsartan Heart Failure Trial [J]. Circulation, 2010, 122 (4): 1387 -1395.
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  • 3Norozi K, Buchhorn R, Yasin A, et al. Growth differentiation factor 15: an additional diagnostic tool for the risk stratification of developing heart failure in patients with operated congenital heart defects? [J]. Am Heart J, 2011, 162 (1): 131- 135.
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  • 5Bootcov MR, Bauskin AR, Valenzuela SM, et al. MIC-l, a novel macrophage inhibitory cytokine , is a divergent member of the TGF-beta superfamily [J]. Proc Nat! Acad Sci USA, 1997, 94 (21): 11514 - 11519.
  • 6Brown DA, Breit SN, Buring J, et al. Concentration in plasma of macrophage inhibitory cytokine - 1 and risk of cardiovascular events in women: a nested case-control study [J]. Lancer, 2002, 359 (9324) : 2159 - 2163.
  • 7Eitel I, Blase P, Adams V, et al. Growth - differentiation factor 15 as predictor of mortality in acute reperfused ST-elevation myocardial infarction: insights from cardiovascular magnetic resonance [J]. Heart, 2011, 97 (8): 632-640.
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  • 10Eggers KM.Kempf Tv Lagerqvist Bvet al. Growth-differentiation factor - 15 for long term risk prediction in patients stabilized after an episode of non-ST-segment-elevation acute coronary syndrome[J]. Circ Cardiovasc Genet,2010,3(1) :88 - 96.

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心血管病学进展
2010年 第4期

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