尼莫地平在脑出血的应用

The application of nimodipine in cerebral hemorrhage

目的观察尼莫地平早期用于轻、中度脑出血的临床疗效及安全性,旨在研究其对血肿变化,脑水肿及神经功能的影响。方法 128例脑出血患者随机分为A组(尼莫地平治疗组),B组(对照组),在入院时,治疗后第3、7、14天作头颅CT测量其脑血肿、脑水肿体积,行中国脑卒中临床神经功能缺损程度评分,比较其治疗效果。结果治疗第3天,两组血肿、神经功能缺损均有加重,两组差异无统计学意义;两组脑水肿均有加重,A组较轻。第7天,两组血肿均有缩小,治疗组缩小较好;脑水肿、神经功能缺损均有恶化,但治疗组较好。第14天,两组脑血肿、脑水肿、神经功能缺损均有明显好转,但治疗组好转较明显。结论尼莫地平早期用于轻、中度脑出血安全、有效,可促进血肿吸收,减轻脑水肿,改善神经功能。

Objective To observe the efficacy and safety of nimodipine for mild to moderate cerebral hemorrhage in the early,to study the changes on the hematoma,brain edema and neurological function.Methods 128 patients with cerebral hemorrhage were randomly divided into A （nimodipine treatment group）,B （control group）,in admission,3,7,14 days after treatment for head CT measurement of the cerebral hematoma,cerebral edema volume of neurological deficit score and compare their treatment.Results 3 days after treatmen,two groups of hematoma,neurological deficits have increased,no significant difference between the two groups;the two groups had increased brain edema,group A of light.7 days,two groups have reduced hematoma,A group of narrow well;cerebral edema,neurological deficits have worsened,but the treatment group is better.14 days,two groups of brain hematoma,cerebral edema,neurological deficits were markedly improved,but the treatment group improved more significantly.Conclusion Nimodipine is safe and effective for mild to moderate cerebral hemorrhage in the early,it can promote Absorption of hematoma and cerebral edema and improve neurological function.