住院患者鲍氏不动杆菌的分布与耐药性分析

Analysis of Drug-resistance and Clinical Distribution of Acinetobacter Baumannii Isolated from Hospitalized Patients

目的研究住院患者鲍氏不动杆菌的临床分布特点,分析其耐药状况,为临床用药提供依据。方法对2007～2009年医院住院患者各类标本中分离的鲍氏不动杆菌作药敏试验,按美国临床实验室标准化研究所(CLSI)2005年标准判断结果。结果共分离到鲍氏不动杆菌162株,主要分离自痰液、血液、尿液及伤口分泌物等标本,以ICU、神经外科、呼吸科和肿瘤化疗的住院患者为主。鲍氏不动杆菌对亚胺培南、多黏菌素E最敏感。结论住院患者的鲍氏不动杆菌感染逐年增长;亚胺培南、多黏菌素E是治疗鲍氏不动杆菌感染最有效的抗生素。

Objective To investigate drug-resistance and clinical distribution characteristics of Acinetobacter banmannii isolated from hospitalized patients and offer scientific basis for reasonable usage of antibiotics.Methods The drug-resistance of Acinetobacter baumannii isolated from the clinical specimens of the inpatients in our hospital between 2007 and 2009 were tested.We got the results according to 2005 standard of CLSI.Results Totally 162 A.baumannii stains were mainly isolated from sputum,blood,urinate and wound secretion.The main clinical wards were from ICU,neurosurgical,respiratory,tumor chemotherapy departments.The most sensitive drugs tested for Acinetobacter baumannii were Imipenem and polymyxin E.Conclusion Infections of Acinetobacter baumannii increase year by year among inpatients.Imipenem and polymyxin E are the most effective antibiotics for Acinetobacter baumannii.