2型糖尿病合并急性心肌梗死早期生化指标评析

Analysis of Biochemical Markers in Type 2 Diabetes Mellitus Patients with Acute Myocardial Infarction

目的探讨肌钙蛋白Ι(cTnI)、B型钠尿肽(BNP)和超敏C反应蛋白(hsCRP)在2型糖尿病(T2DM)合并急性心肌梗死(AMI)患者早期诊断中的价值。方法采集32例T2DM合并AMI(T2DM)患者、40例非DM的AMI(NDM)患者血样本,比较cTnI、BNP和hsCRP水平的变化,并对累及梗死部位进行比较。结果 T2DM组的BNP和hsCRP水平高于NDM组,差异有统计学意义(P<0.01),两组cTnI水平的差异无统计学意义(P>0.05);联合检测阳性率高于单项测定值;冠状动脉造影提示T2DM组冠脉多部位病变发生率高(P<0.05)。结论 cTnI、BNP和hsCRP联合检测对T2DM合并AMI患者的早期诊断具有重要价值。

Objective To investigate the early diagnosis value of type 2 diabetes mellitus patients with acute myocardial infarction by detecting troponin （cTnI）, B-type natriuretie peptide （BNP） and high sensitive C-reactive protein （hsCRP）. Methods 32 eases of type 2 diabetes mellitus with acute myocardial infarction and 40 eases of non-diabetes acute myocardial infarction were collected for a comparative analysis of concentration and site of infarction identified by coronary arteriongraphy. Results In comparison to non-diabetic group,diabetic group demonstrated significantly elevated levels of BNP and hsCRP （P〈0. 01）,but there was no significant difference with eTnI （P〉0. 05）. Combination of cTnI,BNP and hsCRP measurements maybe highly effective for diagnosis. Furthermore,coronary arteriongraphy indicated that pathological changes were more complicated in diabetic group （P〈0. 05）. Conclusion The concentration of cTnI,BNP and hsCRP may provide an important evidence in the early diagnosis of type 2 diabetes mellitus patients with acute myocardial infarction.