氟康唑与伊曲康唑预防造血干细胞移植真菌感染的效果

A comparison of effect of fluconazole and itraconazole in preventing early invasive fungal infection in patients after allogeneic hematopoietic stem cell transplantation

目的比较异基因造血干细胞移植患者应用氟康唑和伊曲康唑预防侵袭性真菌感染的疗效。方法回顾分析115例异基因造血干细胞移植患者,其中应用氟康唑60例,伊曲康唑55例,比较两组患者侵袭性真菌感染的发生转归情况。结果氟康唑组和伊曲康唑组侵袭性真菌感染的发生率分别为8.3%和5.5%,二者差异无统计学意义(P=0.719),发生部位都以肺部为主,中位发生时间无明显差异;伊曲康唑副反应较大(P=0.038)。结论氟康唑与伊曲康唑预防异基因造血干细胞移植早期侵袭性真菌感染效果相近,氟康唑成本低、副作用少,更适合应用于异基因造血干细胞移植早期真菌感染的预防。

Aim To compare the effects of fluconazole and itraconazole in preventing early invasive fungal infection in patients after allogeneic hematopoietic stem cell transplantation.Mthods There 115 cases were divided into fluconazole group consisted of 60 patients treated with fluconazole and and itraconazole group consited of 55 patients treated with itraconazole after allogeneic hematopoietic stem cell transplantation.The occurrence and prognosis of invasive fungal infection between the two groups were compared.Results The incidence rates of invasive fungal infection in fluconazole group and itraconazole group were 8.3% and 5.5%.without significant difference（P=0.719）.Conclusions The effect of fluconazole and itraconazole is similar in preventing early invasive fungal infection in patients after allogeneic hematopoietic stem cell transplantation.