枸橼酸莫沙必利片治疗胃食管反流病115例临床观察

Effect of mosapride citrate tablets on 115 gastroesphageal reflux disease cases

目的比较枸橼酸莫沙比利片,雷贝拉唑,硫糖铝片与吗丁啉,雷贝拉唑,硫糖铝治疗胃食管反流病近期疗效。方法将115例经内镜等检查明确诊断为胃食管反流病的门诊及住院患者,随机分为治疗组(65例)采用枸橼酸莫沙必利片,雷贝拉唑,硫糖铝治疗对照组(50例)用吗丁啉,雷贝拉唑,硫糖铝不治疗;疗程6周。结果治疗组和对照组治疗6周后总有效率、胸骨后疼痛、反酸、烧心及内镜下食管粘膜炎症恢复总有效率分别为95.3%、90.5%、86.6%、92.8%、93.8%和84.0%、80.0%、70.8%、72.7%、82.0%;半年复发率分别为11.0%和23.0%,二组比较治疗总有效率差异有统计学意义(P<0.05)。结论枸橼酸莫沙必利片治疗胃食管反流病效果较好,无明显的不良反应。

Aim To observe the effect and recrudesce of Mosapride citrate tablets on refractory gastroesophageal reflux disease.Methods There 115 of outpatients and inpatients cases with gastroesophageal reflux disease were randomly divided into treatment group（65 cases）treated with mosapride citrate tablets,rabeprazol combined with sucralfate tablets,and control groups（50 cases） treated with domperidone,rabeprazo combined with sucralfate tablets for 6 weeks.Results After treatment the total effective rates recurrent rates in the treatment groups were 95.3% and 11.0%,while that in the control group were 84.0% and 23.0%,all showing significant difference between the two groups（P0.05）.Conclusion Mosapride citrate tablet is effective on refractory gastroesophageal reflux disease without adverse reaction.