胺碘酮与利多卡因治疗急性心梗并室性心律失常疗效观察

Effect of amiodarone and lidocaine on acute myocardial infarction patients complicated with centricular arrhythmia

目的探讨胺碘酮与利多卡因治疗急性心梗并室性心律失常的疗效及安全性。方法急性心肌梗死并发心力衰竭时发生室性心律失常患者共58人,随机分为胺碘酮组30例(在常规治疗AMI的基础上应用可达龙治疗)和利多卡因组28例(在常规治疗AMI的基础上应用利多卡因治疗),观察两组治疗效果。结果胺碘酮组25例室性心律失常得到控制,治疗有效率83.3%(25/30例),总有效率为93.3%(28/30例),病死率6.7%(2/30例)。利多卡因组15例室性心律失常得到控制,治疗有效率53.6%(15/28例),总有效率为85.7%(24/28),病死率14.3%(4/28例)。两组相比,胺碘酮组治疗有效率高于利多卡因组(P<0.05),两组差异有统计学意义。但胺碘酮组和利多卡因组两种药物治疗的病死率比较,在统计学上无差异(P>0.1)。两组药物不良反应总的发生率,利多卡因组较胺碘酮组为高(P<0.005),两组差异有统计学意义。结论胺碘酮相对于传统的抗心律失常药利多卡因对急性心肌梗死并发心力衰竭时发生的室性心律失常有更好的治疗作用,安全、有效,可作为首选的治疗药物。

Aim To observe the effect of amiodarone and lidocaine on acute myocardial infarction cases complicated with ventricular arrhythmia efficacy and safety.Methods There were 58 acute myocardial infarction cases combined with heart failure happening ventricular arrhythmia were divided into amiodarone group（n=30）and lidocaine group（n=28）.The results in the two groups were analyzed.Results The effective rate of amiodarone Group was 83.3%（25/30）,the total effectiverate was 93.3%（28/30cases） and the fatality rate was 6.7%（2/30）.The effective and total effective rate of lidocaine group were 53.6%（15/28）and 85.7%（24/28）and the fatality rate was 14.3%（4/28）.Significant difference in effective rate between the two groups were observed（P0.05）.Conclusion Compared with lidocaine,the conventional antiarrhythmic drug,amiodarone is more effective on acute myocardial infarction patients combined with ventricular arrhythmia.