对萼猕猴桃叶中的四个具有细胞毒活性的三萜类成分(英文)

Four Triterpenoids with Cytotoxic Activity from the Leaves of Actinidia valvata

目的:研究对萼猕猴桃(Actinidia valvata Dunn)叶的的化学成分进行研究。方法:采用多种色谱手段进行分离,通过波谱分析确定化合物结构。选用肿瘤细胞株PLC、Hep3B、HepG2、HeLa、SW480、MCF-7和Bel7402,采用MTT法进行细胞毒活性测试。结果:从对萼猕猴桃中分得4个化合物为科罗索酸(1)、2α,3β,24-三羟基乌苏烷-12-烯-28-酸(2)、2α,3α,24-三羟基乌苏烷-12-烯-28-酸(3)和2α,3α,19α,24-四羟基乌苏烷-12-烯-28-酸(4),它们都具有细胞毒活性。结论:该4个化合物为首次从该实验材料中获得。

AIM：To study the chemical constituents of the leaves of Actinidia valvata Dunn.METHODS：Several chromatographic methods were applied to isolate and purify compounds and their structures were elucidated by spectroscopic methods.RESULTS：Four triterpenoids including corosolic acid（1）,2α,3β,24-trihydroxyurs-12-en-28-oic acid（2）,2α,3α,24-trihydroxyurs-12-en-28-oic acid（3） and 2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid（4） were isolated from Actinidia valvata Dunn.They all showed in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.CONCLUSION：These 4 compounds were all obtained from the plant for the first time.