心脏性猝死急救中预防性应用胺碘酮的效果观察

Study on prophylactic application of amiodarone in emergency treatment of the patients with sudden cardiac death

目的探讨在心脏性猝死(SCD)急救中预防性应用胺碘酮对降低病死率,减少除颤次数和不良反应发生率的效果。方法采用前瞻性随机对照原则,将心脏性猝死患者30例,分为预防性应用胺碘酮实施组和常规治疗组(对照组),实施组15例,对照组15例。统计除颤次数,死亡、不良反应例数。结果实施组和对照组除颤次数分别为(1.3±0.1)次和(4.86±O.5)次(P<O.01);病死率分别为40.0%和80.0%(P<0.05);实施组不良反应2例。结论心脏性猝死急救中,预防性应用胺碘酮可显著降低除颤器的使用率,增加抢救成功率,无严重不良反应。

Objective To explore the effect of prophylactic application of amiodarone in emergency treatment of patients with sudden cardiac death and its safety. Methods Thirty patients with sudden cardiac death were randomly divided into two groups： amiodarone prophylactic application group and routine treatment group with 15 patients in each group. The times of defibrillation and cases of death and adverse reaction were statistically analyzed. Results The times of defibrillation were （ 1.3 ± 0. 1 ） in amiodarone prophylactic application group and （4. 86 ± 0. 5） in routine treatment group （ P 〈 0. 01 ）. The death rate were 40% in amiodarone prophylactic application group and 80% in routine treatment group （ P 〈 0. 05 ）. Adverse reactions were observed in 2 patients in amiodarone prophylactic application group. Conclusion Prophylactic application of amiedarone in emergency treatment of patients with sudden cardiac death can significantly decrease the utilization rate of defibrillator, increase the rate of successful rescue with no severe adverse reaction.