血清半胱氨酸蛋白酶抑制剂C对新生儿窒息后肾功能的评价

Effect of serum cystatin C in assessment of renal function in neonates with asphyxia

目的观察血清半胱氨酸蛋白酶抑制剂C((Cystatin C,简称Cys C)对新生儿窒息后。肾滤过功能的影响。方法应用酶联免疫吸附法(ELISA)对68例新生儿窒息(轻度40例,重度28例)及对照组28例新生儿血清中Cys C的水平以及血肌酐、尿素氮进行测定。采用SPSS11.0软件对数据进行统计学方差分析和t检验。结果窒息组血Cys C较对照组显著增高。轻度窒息组血肌酐、尿素氮与对照组比较差异无统计学意义,但重度窒息组血肌酐、尿素氮与对照组比较差异有统计学意义。在新生儿窒息时Cys C水平升高,但随着病情的缓解,Cys C水平下降。结论新生儿窒息后肾小球滤过功能会受损,血Cys C是评价肾小球滤过功能敏感的检测指标。

Objective To explore the changes of serum cystatin C in neonate with asphyxia,and evaluate its effect on function of glomerular filtration. Methods Serum cystatin C, blood urea nitrogen （BUN） and creatinine （Cr） of neonates in asphyxia group and of neonates in the control group were measured by enzyme-linked immunosorbent assay （ELISA）. Results Cystatin C obviously inreased in neonates with asphyxia, compared with control group. There were no significant difference in serum BUN and Cr levels between the mild asphyxia group and the control group. Levels of serum cystatin C was incrased in severe asphyxia. Serum CysC levels in the asphyxia group were significantly higher than those in the control group （ P 〈 0.01 ）. After the treatment, levels of serum cystatin C decreased. Conclusion Serum Cys C can be considered as a marker of damage function of glomerular filtration in neonates with asphyxia.