摘要
肥胖的发生伴随着脂肪组织结构的重塑，脂肪生成和血管新生是其中重要的环节。脂肪生成与血管新生是时间及空间上相互耦联的进程。血管新生涉及促血管性因子（包括瘦素、血管内皮生长因子等）、血管生成抑制因子（如脂联素、内皮抑素等）及细胞外蛋白酶解系统等诸多因素的相互作用。此外，过氧化物酶体增殖物活化受体（PPARs）配体亦在血管新生过程中扮演重要的角色。调节脂肪组织的血管新生，为预防及治疗肥胖及其相关代谢紊乱提供新的治疗观念。
Development of obesity is associated with substantial remodeling of adipose tissue structure, involving adipogenesis and angiogenesis. Angiogenesis and adipogenesis are temporally and spatially coupled processes. Angiogenesis involves in the interaction of angiogenic factors （leptin, vascular endothelial growth factor） , angiogenesis inhibitors （adiponectin, endostatin） and proteolysis system. In addition, peroxi-some proliferator-activated receptors （ PPARs） also play important roles in the process of angiogenesis. Thus,modulation of angiogenesis in adipose tissue provides a novel therapeutic option for prevention and treatment of human obesity and its related disorders.
出处
《国际内分泌代谢杂志》
2010年第4期221-223,共3页
International Journal of Endocrinology and Metabolism
关键词
肥胖
血管新生
脂肪生成
Obesity
Angiogenesis
Adipogenesis
