酮咯酸氨丁三醇联合舒芬太尼用于子宫全切术后镇痛的研究

Research on analgesia of Ketorolac Tromethamine combined with Sufentanil for total hysterectomy

目的:在妇科子宫全切术中联合应用酮咯酸氨丁三醇和舒芬太尼静脉自控镇痛(PICA),评价其镇痛效果及临床可行性。方法:选择妇科子宫全切术术后行静脉自控镇痛患者40例,随机分为两组,舒芬太尼组(A组)20例,舒芬太尼复合酮咯酸氨丁三醇组(B组)20例。术后24h持续监测SpO2、ECG、NBP,并进行VAS评分,观察可能出现的不良反应。结果:两组镇痛效果比较,无显著性差异(P>0.05),但B组患者头昏、恶心、呕吐以及瘙痒等副作用明显低于A组(P<0.05)。结论:舒芬太尼复合酮咯酸氨丁三醇与单纯舒芬太尼比较,能明显减弱舒芬太尼产生的头昏、恶心、呕吐以及瘙痒等副作用,并且可以增强舒芬太尼的镇痛效果,减少舒芬太尼的用量。

Objective：Ketorolac Tromethamine was applied together with Sufentanil during patient-controlled intravenous analgesia for total hysterectomy so as to evaluate its analgesic efficacy and clinical feasibility.Methods：40 cases of total hysterectomy with postoperative patient-controlled intravenous analgesia were selected and randomly divided into two groups：group A of 20 cases was treated with Sufentanil only while group B of another 20 cases was treated with Ketorolac Tromethamine combined with Sufentanil.SpO2,ECG and NBP were monitored for 24 hours after operation to get VAS scores while observing any possible adverse reaction.Results：There was no significant difference in analgesic efficacy between the two groups（P0.05）,but the adverse reactions like dizziness,nausea,vomiting and pruritus in group B were obviously lower than those in group A（P0.05）.Conclusion：Compared with the treatment with Sufentanil only,Ketorolac Tromethamine combined with Sufentanil can notably reduce the adverse reactions like dizziness,nausea,vomiting and pruritus,which were caused by Sufentanil.What＇s more,this approach can also enhance the analgesic efficacy of Sufentanil while reducing its dosage.